Yes, these problems have largely been solved. Smalltalk is excellent for web development. Smalltalk integrates with C/C++ libraries. Smalltalk is interoperable with Github and other source control systems.

Smalltalk has always been able to do large projects. The DoD's JWARS, for example, was a massive simulation of theatre-level warfare that consisted of 1.1 million lines of Smalltalk code!

The key to using Smalltalk professionally is good project management. It requires discipline such as regular backups and TDD. But this is true of ALL software projects, not just for Smalltalk.

The benefits of using Smalltalk and images are much shorter development time, shorter time to market, lower labour costs. This is why Smalltalk is used as a "secret weapon" against competitors.