In what ways? There are many people who don’t like Python. It has many drawbacks.

Some people simply don’t like the indentation-sensitive syntax; it drives them crazy. A misplaced space character can cause a difficult-to-find bug.

The Global Interpreter Lock (or GIL) is another sore point. It can play havoc with concurrency.

In fact, there are many valid complaints about Python.

Smalltalk, on the other hand, is as pure as the driven snow. It’s hard to find anything wrong with the language. Smalltalk is extremely clean and simple with absolutely no cruft.

Read Why choose Smalltalk over Python for startups.

Also, read Smalltalk and the Future of the Software Industry.